A study initiated by Dr. Dan Theodorescu, a physician-scientist at the University of Arizona Cancer Center, revealed that the loss of the Y chromosome in men's body tissue could pave the way for cancer to develop. According to research recently published in JCI Insights, the loss of the chromosome, which is common in men as they age, creates a preneoplastic field effect, a hidden zone of genetic vulnerability in normal tissue that provides fertile ground for cancer to develop.